|
Synonyms: REGN-1979 | REGN1979
Compound class:
Antibody
Comment: Odronextamab (REGN1979) is a fully human CD3ε/CD20 bispecific IgG4-based antibody that redirects CD3+ cytotoxic T cells to selectively destroy CD20+ve malignant B cells [2]. Fc-mediated effector function has been minimised by modification of the IgG4 Fc domain.
|
| Bioactivity Comments |
| Induces target-dependent lysis of CD20+ve lymphoma cells by human and cynomolgus T cells in vitro (EC50 15-84 pM), and demonstrates anti-tumour activity in in vivo B cell lymphoma models [2]. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
