Synonyms: LY-3473329 | LY3473329
Compound class:
Synthetic organic
Comment: Muvalaplin (LY3473329) is an orally bioavailable small molecule that disrupts the binding of apolipoprotein(a) to apolipoprotein B100, thus blocking the formation of lipoprotein(a) [1]. It was designed to treat atherosclerotic disease. Muvalaplin does not bind to plasminogen.
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Bioactivity Comments |
In human subjects muvalaplin dose-dependently reduced plasma Lp(a) levels by >60% (by day 14) compared to placebo [1]. |