Synonyms: LY-3473329 | LY3473329
Compound class:
Synthetic organic
Comment: Muvalaplin (LY3473329) is an orally bioavailable small molecule that disrupts the binding of apolipoprotein(a) to apolipoprotein B100, thus blocking the formation of lipoprotein(a) [1]. It was designed to treat atherosclerotic disease. Muvalaplin does not bind to plasminogen.
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References |
1. Nicholls SJ, Nissen SE, Fleming C, Urva S, Suico J, Berg PH, Linnebjerg H, Ruotolo G, Turner PK, Michael LF. (2023)
Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial. JAMA, 330 (11): 1042-1053. [PMID:37638695] |