teglicar   Click here for help

GtoPdb Ligand ID: 12976

Synonyms: compound 17 [Giannessi et al., 2003] | ST-1326 | ST1326
PDB Ligand
Compound class: Synthetic organic
Comment: Teglicar (ST1326) is a reversible carnitine palmitoyltransferase inhibitor [2]. It is a substrate analogue that mimics palmitoylcarnitine. Teglicar has been investigated for anti-cancer effects in solid [1] and liquid tumours [3-5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 20
Topological polar surface area 81.26
Molecular weight 399.61
XLogP 5.15
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCCCCCCCCCCNC(=O)N[C@H](CC(=O)[O-])C[N+](C)(C)C
Isomeric SMILES CCCCCCCCCCCCCCNC(=O)N[C@H](CC(=O)[O-])C[N+](C)(C)C
InChI InChI=1S/C22H45N3O3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-23-22(28)24-20(18-21(26)27)19-25(2,3)4/h20H,5-19H2,1-4H3,(H2-,23,24,26,27,28)/t20-/m1/s1
InChI Key BMZYTDRMCBZVNH-HXUWFJFHSA-N
Bioactivity Comments
Quantitative data were determined in mitochondial isolates from rat tissues [2]. Expression of CPT1A is assessed as being most significant in liver (where CPT1B is absent), and CPT1B in heart muscle. However CPT1A can also be detected in heart muscle.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
carnitine palmitoyltransferase 2 Rn Inhibitor Inhibition 6.6 pIC50 - 7
⤷ pIC50 6.6 (IC50 2.4x10-7 M) [7]
carnitine palmitoyltransferase 1A Rn Inhibitor Inhibition 6.0 pIC50 - 2
⤷ pIC50 6.0 (IC50 1.1x10-6 M) [2]
Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh liver mithocondria from male Sprague-Dawley rats
carnitine palmitoyltransferase 1B Rn Inhibitor Inhibition 4.4 pIC50 - 2
⤷ pIC50 4.4 (IC50 4.34x10-5 M) [2]
Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh heart mithocondria from male Sprague-Dawley rats
Targets where the ligand is described in the comment field
Target Comment
carnitine palmitoyltransferase 2 Loss of CPT2 function causes the rare lipid metabolism disorder carnitine palmitoyltransferase II deficiency, where long-chain fatty acids cannot be transported into mitochondria for processing and energy production via β-oxidation. The disorder can manifest as neonatal, infantile and adult forms which differ in their tissue-specific symptoms. The 3D stuctures of rat CPT2 in complex with teglicar (PDB ID 2FW3) [7] and a palmitoyl-carnitine substrate analogue (PDB ID 2RCU) [6] have been resolved.