mianserin

Ligand id: 135

Name: mianserin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 6.48
Molecular weight 264.16
XLogP 4.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2C receptor Rn Antagonist Antagonist 8.8 – 9.4 pKi - 7,17
pKi 8.8 – 9.4 [7,17]
5-HT2C receptor Hs Antagonist Inverse agonist 8.3 – 9.2 pKi - 6,9,14
pKi 8.3 – 9.2 [6,9,14]
5-HT2A receptor Rn Antagonist Antagonist 8.4 – 9.0 pKi - 5,17
pKi 8.4 – 9.0 [5,17]
5-HT2A receptor Hs Antagonist Antagonist 7.7 – 9.6 pKi - 9,11,14
pKi 7.7 – 9.6 [9,11,14]
5-HT2B receptor Hs Antagonist Antagonist 7.9 – 8.8 pKi - 4,9,21
pKi 7.9 – 8.8 [4,9,21]
5-HT1B receptor Mm Antagonist Antagonist 8.3 pKi - 12
pKi 8.3 [12]
α1A-adrenoceptor Hs Antagonist Antagonist 7.6 pKi - 22
pKi 7.6 [22]
α1D-adrenoceptor Hs Antagonist Antagonist 7.5 pKi - 22
pKi 7.5 [22]
5-HT7 receptor Hs Antagonist Antagonist 7.3 – 7.6 pKi - 8
pKi 7.3 – 7.6 [8]
α1B-adrenoceptor Hs Antagonist Antagonist 7.4 pKi - 22
pKi 7.4 [22]
5-HT2B receptor Rn Antagonist Antagonist 7.3 pKi - 20
pKi 7.3 [20]
5-HT7 receptor Rn Antagonist Antagonist 7.0 – 7.4 pKi - 18-19
pKi 7.0 – 7.4 [18-19]
5-HT6 receptor Rn Antagonist Antagonist 6.9 – 7.4 pKi - 1,3,15
pKi 6.9 – 7.4 [1,3,15]
5-HT6 receptor Hs Antagonist Antagonist 6.9 – 7.3 pKi - 2-3,10
pKi 6.9 – 7.3 [2-3,10]
5-HT7 receptor Mm Antagonist Antagonist 7.0 pKi - 16
pKi 7.0 [16]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
NET Rn Inhibitor Inhibition 7.6 pKi - 13
pKi 7.6 (Ki 2.6x10-8 M) [13]
Description: Inhibition of [3H]NE uptake into rat synaptosomes