mianserin

Ligand id: 135

Name: mianserin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 6.48
Molecular weight 264.16
XLogP 4.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2C receptor Antagonist Inverse agonist 8.3 – 9.2 pKi - 6,9,14
pKi 8.3 – 9.2 [6,9,14]
5-HT2A receptor Antagonist Antagonist 7.7 – 9.6 pKi - 9,11,14
pKi 7.7 – 9.6 [9,11,14]
5-HT2B receptor Antagonist Antagonist 7.9 – 8.8 pKi - 4,9,21
pKi 7.9 – 8.8 [4,9,21]
α1A-adrenoceptor Antagonist Antagonist 7.6 pKi - 22
pKi 7.6 [22]
α1D-adrenoceptor Antagonist Antagonist 7.5 pKi - 22
pKi 7.5 [22]
5-HT7 receptor Antagonist Antagonist 7.3 – 7.6 pKi - 8
pKi 7.3 – 7.6 [8]
α1B-adrenoceptor Antagonist Antagonist 7.4 pKi - 22
pKi 7.4 [22]
5-HT6 receptor Antagonist Antagonist 6.9 – 7.3 pKi - 2-3,10
pKi 6.9 – 7.3 [2-3,10]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT1B receptor Antagonist Antagonist 8.3 pKi - 12
pKi 8.3 [12]
5-HT7 receptor Antagonist Antagonist 7.0 pKi - 16
pKi 7.0 [16]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2C receptor Antagonist Antagonist 8.8 – 9.4 pKi - 7,17
pKi 8.8 – 9.4 [7,17]
5-HT2A receptor Antagonist Antagonist 8.4 – 9.0 pKi - 5,17
pKi 8.4 – 9.0 [5,17]
5-HT2B receptor Antagonist Antagonist 7.3 pKi - 20
pKi 7.3 [20]
5-HT7 receptor Antagonist Antagonist 7.0 – 7.4 pKi - 18-19
pKi 7.0 – 7.4 [18-19]
5-HT6 receptor Antagonist Antagonist 6.9 – 7.4 pKi - 1,3,15
pKi 6.9 – 7.4 [1,3,15]
Selectivity at rat transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
NET Inhibitor Inhibition 7.6 pKi - 13
pKi 7.6 (Ki 2.6x10-8 M) [13]
Description: Inhibition of [3H]NE uptake into rat synaptosomes