mianserin

Ligand id: 135

Name: mianserin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 6.48
Molecular weight 264.16
XLogP 4.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of major depressive disorder. There is no information regarding approval for medical use of mianserin on the US FDA website. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of mianserin is not well understood, although its action as an antidepressant is likely due to its antagonism of alpha-adrenergic receptors, histmine H1 receptors and several types of serotonin receptors.