carbacyclin

Ligand id: 1893

Name: carbacyclin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 77.76
Molecular weight 350.25
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Agonist Full agonist 7.8 pKi - 1
pKi 7.8 (Ki 1.4x10-8 M) EP3-III isoform [1]
EP1 receptor Agonist Full agonist 7.6 pKi - 1
pKi 7.6 [1]
DP1 receptor Agonist Full agonist 6.9 pKi - 1
pKi 6.9 [1]
IP receptor Agonist Full agonist 6.5 – 6.6 pKi - 1
pKi 6.5 – 6.6 [1]
EP4 receptor Agonist Full agonist 6.5 pKi - 1
pKi 6.5 [1]
FP receptor Agonist Full agonist 6.4 – 6.5 pKi - 1
pKi 6.4 – 6.5 [1]
EP2 receptor Agonist Full agonist 6.0 pKi - 1
pKi 6.0 [1]
TP receptor Agonist Full agonist 4.7 pKi - 1
pKi 4.7 [1]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Agonist Full agonist 7.5 pKi - 2
pKi 7.5 (Ki 3.1x10-8 M) [2]
IP receptor Agonist Full agonist 7.0 pKi - 2
pKi 7.0 [2]
FP receptor Agonist Full agonist 5.9 pKi - 2
pKi 5.9 [2]
EP2 receptor Agonist Full agonist 5.8 pKi - 2
pKi 5.8 [2]
EP4 receptor Agonist Full agonist 5.6 pKi - 2
pKi 5.6 [2]