enprostil

Ligand id: 1918

Name: enprostil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 93.06
Molecular weight 400.19
XLogP 3.82
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
EP3 receptor Hs Agonist Full agonist 7.9 pKi - 1
pKi 7.9 (Ki 1.2x10-8 M) EP3-III isoform [1]
EP1 receptor Hs Agonist Full agonist 7.1 – 7.8 pKi - 1,4
pKi 7.1 – 7.8 [1,4]
EP4 receptor Hs Agonist Full agonist 7.4 pKi - 3
pKi 7.4 [3]
EP3 receptor Rn Agonist Full agonist 7.1 pKi - 2
pKi 7.1 (Ki 7.4x10-8 M) EP3α isoform [2]
FP receptor Hs Agonist Full agonist 7.1 pKi - 1
pKi 7.1 [1]
EP1 receptor Rn Agonist Full agonist 6.7 pKi - 2
pKi 6.7 [2]
EP3 receptor Hs Agonist Full agonist 8.4 pEC50 - 5
pEC50 8.4 (EC50 3.7x10-9 M) [5]