relaxin-3   Click here for help

GtoPdb Ligand ID: 1990

Synonyms: H3 relaxin
Compound class: Endogenous peptide in human, mouse or rat
Comment: A heterodimer containing disulfide-linked A and B subunits that are each cleaved from the relaxin 3 gene (RLN3) product.
Species: Human
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
Natural/Endogenous Targets
Target
RXFP1
RXFP2
RXFP3
RXFP4
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
RXFP4 Ligand is endogenous in the given species Hs Agonist Full agonist 8.8 – 9.0 pKi - 7,10,12,17
⤷ pKi 9.0 [10,12]
pKi 8.8 – 8.8 [7,17]
RXFP3 Ligand is endogenous in the given species Hs Agonist Full agonist 7.8 – 8.9 pKi - 5,13,16
⤷ pKi 7.8 – 8.9 [5,13,16]
RXFP1 Ligand is endogenous in the given species Hs Agonist Full agonist 7.5 – 8.0 pKi - 4,14
⤷ pKi 7.5 – 8.0 [4,14]
RXFP2 Ligand is endogenous in the given species Hs Agonist Full agonist 7.0 pKi - 2
⤷ pKi 7.0 [2]
RXFP4 Hs Agonist Full agonist 8.7 – 9.7 pEC50 - 1,17
⤷ pEC50 8.7 – 9.7 [1,17]
RXFP3 Hs Agonist Full agonist 8.3 – 9.9 pEC50 - 5-6,13,15-16
⤷ pEC50 8.3 – 9.9 [5-6,13,15-16]
RXFP3 Ligand is endogenous in the given species Hs Agonist Full agonist 9.4 – 9.6 pIC50 - 3,11
⤷ pIC50 9.4 – 9.6 [3,11]
RXFP4 Ligand is endogenous in the given species Hs Agonist Full agonist 8.8 – 9.0 pIC50 - 1,7,12
⤷ pIC50 8.8 – 9.0 [1,7,12]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order of endogenous ligands at RXFP2 INSL3 (INSL3, P51460) > relaxin (RLN2, P04090) >> relaxin-3 (RLN3, Q8WXF3) 8,14
Potency order of endogenous ligands at RXFP1 relaxin (RLN2, P04090) = relaxin-1 (RLN1, P04808) > relaxin-3 (RLN3, Q8WXF3) 14
Potency order of endogenous ligands at RXFP4 INSL5 (INSL5, Q9Y5Q6) = relaxin-3 (RLN3, Q8WXF3) > relaxin-3 (B chain) (RLN3, Q8WXF3) 9-10
Potency order of endogenous ligands at RXFP3 relaxin-3 (RLN3, Q8WXF3) > relaxin-3 (B chain) (RLN3, Q8WXF3) > relaxin (RLN2, P04090) 11
Ligand mentioned in the following text fields
Relaxin family peptide receptors overview
Relaxin family peptide receptors comments