apamin

Ligand id: 2311

Name: apamin

Structure and Physico-chemical Properties

2D Structure

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
KCa2.2 Hs Inhibitor - 9.4 pKd - 4
pKd 9.4 (Kd 3x10-10 M) [4]
KCa2.2 Rn Channel blocker Antagonist 10.1 – 10.2 pIC50 - 5,8
pIC50 10.1 – 10.2 [5,8]
KCa2.3 Rn Channel blocker Antagonist 8.9 – 9.2 pIC50 - 1,3
pIC50 8.9 – 9.2 [1,3]
KCa2.3 Hs Inhibitor - 7.9 – 9.1 pIC50 - 9,11
pIC50 7.9 – 9.1 (IC50 1.32x10-8 – 8x10-10 M) [9,11]
KCa2.1 Hs Inhibitor - 7.9 – 8.5 pIC50 - 6-8
pIC50 7.9 – 8.5 (IC50 1.2x10-8 – 3.3x10-9 M) [6-8]
Targets where the ligand is described in the comment field
Target Comment