niflumic acid

Ligand id: 2439

Name: niflumic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 62.22
Molecular weight 282.06
XLogP 4.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find affinity data for this drug (at the human targets) to substantiate its MMOA.
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv7.1 Activator Positive - - 1x10-4 1
Conc range: 1x10-4 M [1]
KNa1.2 Activator Agonist 8.7 pEC50 - 2-3
pEC50 8.7 (EC50 2.1x10-9 M) [2-3]
ClC-Ka Activator - 3.0 – 5.0 pEC50 -
pEC50 3.0 – 5.0 (EC50 1x10-3 – 1x10-5 M)
ClC-Kb Activator - 3.0 – 5.0 pEC50 -
pEC50 3.0 – 5.0 (EC50 1x10-3 – 1x10-5 M)
ClC-Ka Channel blocker - >- pIC50 -
pIC50 (IC50 <1x10-3 M)
ClC-1 Channel blocker - - - -
CaCC Channel blocker - - - -
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPC4 Channel blocker Antagonist - - 3x10-5 5
Conc range: 3x10-5 M [5]
Voltage: -60.0 mV
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPA1 Activator Activation 3.3 pEC50 - 4
pEC50 3.3 [4]
Voltage: -100.0 mV
Description: Two electrode voltage clamp
Conditions: Xenopus oocytes expressing rat TRPA1
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields