niflumic acid

Ligand id: 2439

Name: niflumic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 62.22
Molecular weight 282.06
XLogP 4.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Busch AE, Herzer T, Wagner CA, Schmidt F, Raber G, Waldegger S, Lang F. (1994)
Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes.
Mol. Pharmacol.46 (4): 750-3. [PMID:7969055]
2. Dai L, Garg V, Sanguinetti MC. (2010)
Activation of Slo2.1 channels by niflumic acid.
J. Gen. Physiol.135 (3): 275-95. [PMID:20176855]
3. Garg P, Sanguinetti MC. (2012)
Structure-activity relationship of fenamates as Slo2.1 channel activators.
Mol. Pharmacol.82 (5): 795-802. [PMID:22851714]
4. Hu H, Tian J, Zhu Y, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX. (2010)
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Pflugers Arch.459 (4): 579-92. [PMID:19888597]
5. Walker RL, Koh SD, Sergeant GP, Sanders KM, Horowitz B. (2002)
TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal.
Am. J. Physiol., Cell Physiol.283 (6): C1637-45. [PMID:12388058]