BCTC

Ligand id: 2460

Name: BCTC

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 48.47
Molecular weight 372.17
XLogP 5.22
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV1 Channel blocker Antagonist 7.5 pIC50 - 2
pIC50 7.5 (IC50 3.49x10-8 M) [2]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPM8 Channel blocker Antagonist 6.1 pIC50 - 1
pIC50 6.1 (IC50 8x10-7 M) [1]
Voltage: Physiological
Description: Whole-cell voltage-clamp recordings or Ca2+-microfluorimetry in heterologous cells (HEK, CHO, and Xenopus oocytes) expressing TRPM8
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV1 Channel blocker Antagonist 7.5 pIC50 - 3
pIC50 7.5 [3]
Voltage: Physiological