lamotrigine

Ligand id: 2622

Name: lamotrigine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 90.71
Molecular weight 255.01
XLogP 1.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find publicly available affinity data for this drug (at its proposed human targets) to substantiate its MMOA. For this reason, we have not tagged a primary drug target.
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Nav1.2 Channel blocker Pore blocker 4.5 pIC50 - 1-2
pIC50 4.5 [1-2]
Voltage: -50.0 mV