lamotrigine

Ligand id: 2622

Name: lamotrigine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 90.71
Molecular weight 255.01
XLogP 1.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Liu G, Yarov-Yarovoy V, Nobbs M, Clare JJ, Scheuer T, Catterall WA. (2003)
Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels.
Neuropharmacology44 (3): 413-22. [PMID:12604088]
2. Xie X, Lancaster B, Peakman T, Garthwaite J. (1995)
Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones.
Pflugers Arch.430 (3): 437-46. [PMID:7491269]