Ligand Id: 2718
Ligand name cholesterol

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 20.23
Molecular weight 386.35
XLogP 10.52
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
RAR-related orphan receptor-α Agonist Agonist - - - 1-2
Receptors where the ligand is described in the comment field
Receptor Comment
CYP11A1 Converts cholesterol to pregnenolone

Selectivity data from IUPHAR-DB

Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
RAR-related orphan receptor-α Agonist Agonist - - - 1-2

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org