dihydrosphingosine 1-phosphate

Ligand id: 2921

Name: dihydrosphingosine 1-phosphate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 18
Topological polar surface area 122.82
Molecular weight 381.26
XLogP 5.04
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Target
GPR63
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GPR63 Hs Agonist Full agonist 6.2 pEC50 - 4
pEC50 6.2 (EC50 6.8x10-7 M) [4]
S1P4 receptor Hs Agonist Agonist 8.0 pIC50 - 2
pIC50 8.0 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference