Natural/Endogenous Targets
Target MC1 receptor MC3 receptor MC4 receptor MC5 receptor

Additional information and targets (data relate to human unless otherwise stated)
Description	Data	Reference
Potency order of endogenous agonists at MC1 receptor	α-MSH (POMC, P01189) > β-MSH (POMC, P01189) > ACTH (POMC, P01189), γ-MSH (POMC, P01189)
Potency order of endogenous agonists at MC3 receptor	γ-MSH (POMC, P01189), β-MSH (POMC, P01189) > ACTH (POMC, P01189), α-MSH (POMC, P01189)
Potency order of endogenous agonists at MC4 receptor	β-MSH (POMC, P01189) > α-MSH (POMC, P01189), ACTH (POMC, P01189) > γ-MSH (POMC, P01189)
Potency order of endogenous agonists at MC5 receptor	α-MSH (POMC, P01189) > β-MSH (POMC, P01189) > ACTH (POMC, P01189) > γ-MSH (POMC, P01189)

Ligand mentioned in the following text fields
Melanocortin receptors overview