AF353

Ligand id: 4125

Name: AF353

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 96.28
Molecular weight 400.04
XLogP 2.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
P2X3 Antagonist Antagonist ~8.0 pIC50 - 1
pIC50 ~8.0 (IC50 ~1x10-8 M) [1]