AF353

Ligand id: 4125

Name: AF353

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 96.28
Molecular weight 400.04
XLogP 2.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, Rubas W, Oglesby IB, Dillon MP, Milla ME et al.. (2010)
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.
Br. J. Pharmacol.160 (6): 1387-98. [PMID:20590629]