Ligand id: 4177

Name: DIDS

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 214.4
Molecular weight 453.94
XLogP 4.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
DIDS dose-dependently inhibits the ABCA1-specific anion efflux when the transporter is expressed in Xenopus oocytes [2]. DIDS also dose-dependently, and selectively inhibits inhibit IL-1β secretion, indicating a pharmacological relationship between ABCA1, IL-1β [3] and modulation of the inflammasome [1].
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ClC-7 Hs Channel blocker - 4.4 pIC50 - 4
pIC50 4.4 (IC50 4x10-5 M) [4]
Maxi Cl- Hs Channel blocker - 4.4 pIC50 - 4
pIC50 4.4 (IC50 4x10-5 M) [4]
ClC-6 Hs Channel blocker - 3.0 pIC50 -
pIC50 3.0 (IC50 1x10-3 M)
ClC-Ka Hs Channel blocker - - - -
ClC-Kb Hs Channel blocker - - - -
CaCC Hs Channel blocker - - - -
VRAC Hs Channel blocker - - - -
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields