Ligand id: 4190

Name: felodipine

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View more information in the IUPHAR Pharmacology Education Project: felodipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 64.63
Molecular weight 383.07
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In addition to action as a voltage-gated L-type calcium channel blocker, ChEMBL list this drug as an antagonist of the mineralocorticoid receptor, NR3C2. However, we have been unable to find publicly available bioactivity data for this drug at any of its proposed molecular target(s), and have therefore not tagged a primary drug target.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CFTR Hs Activator Potentiation 8.4 pKi - 1
pKi 8.4 (Ki 4x10-9 M) [1]
Targets where the ligand is described in the comment field
Target Comment