Ligand id: 4190

Name: felodipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 64.63
Molecular weight 383.07
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Felodipine is used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Felodipine inhibits calcium-dependent myocyte contraction/vasoconstriction (effectively causing vasodilation and lowering blood pressure) by holding voltage-gated L-type calcium channels in their inactive conformation.