Ligand Id: 4290
Ligand name pregnenolone sulphate

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 89.05
Molecular weight 396.2
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
Transporters
Transporter DB page EC number Reaction Reference
Sodium/bile acid cotransporter 6 View in GRAC 1

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
α1 Antagonist Antagonist 5.7 pKi -
α2 Antagonist Antagonist 5.3 pKi -
β (when co-expressed with the α1 subunit) Antagonist Antagonist 5.6 pKi -
β (when co-expressed with the α2 subunit) Antagonist Antagonist 5.0 pKi -
TRPM1 Activator - - - - 3
TRPM3 Activator - - - - 2

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org