phenylephrine

Ligand id: 485

Name: phenylephrine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 52.49
Molecular weight 167.09
XLogP 0.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α1D-adrenoceptor Rn Agonist Full agonist 5.9 pKi - 2
pKi 5.9 [2]
α1A-adrenoceptor Hs Agonist Full agonist 5.2 – 5.4 pKi - 3
pKi 5.2 – 5.4 [3]
α1B-adrenoceptor Hs Agonist Full agonist 6.3 – 7.5 pIC50 - 1-2
pIC50 6.3 – 7.5 [1-2]
Ligand mentioned in the following text fields