tamsulosin

Ligand id: 488

Name: tamsulosin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 108.26
Molecular weight 408.17
XLogP 2.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1A-adrenoceptor Antagonist Antagonist 10.0 – 10.7 pKi - 1-3,5-6
pKi 10.0 – 10.7 [1-3,5-6]
α1D-adrenoceptor Antagonist Antagonist 9.8 – 10.2 pKi - 3,5-6
pKi 9.8 – 10.2 [3,5-6]
α1B-adrenoceptor Antagonist Inverse agonist 9.5 – 9.7 pKi - 3,5-6
pKi 9.5 – 9.7 [3,5-6]
Ligand mentioned in the following text fields