tamsulosin

Ligand id: 488

Name: tamsulosin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: tamsulosin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 108.26
Molecular weight 408.17
XLogP 2.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α1A-adrenoceptor Hs Antagonist Antagonist 10.0 – 10.7 pKi - 1-3,5-6
pKi 10.0 – 10.7 [1-3,5-6]
α1D-adrenoceptor Hs Antagonist Antagonist 9.8 – 10.2 pKi - 3,5-6
pKi 9.8 – 10.2 [3,5-6]
α1B-adrenoceptor Hs Antagonist Inverse agonist 9.5 – 9.7 pKi - 3,5-6
pKi 9.5 – 9.7 [3,5-6]
Ligand mentioned in the following text fields