dorsomorphin

Ligand id: 4907

Name: dorsomorphin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 55.55
Molecular weight 399.21
XLogP 3.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Dorsomorphin also has inhibitory activity at other kinases as detailed in the Bioactivity table below. Note that some bioactivity data may be associated with dorsomorphin dihydrochloride (PubChem CID 49761481).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SRC proto-oncogene, non-receptor tyrosine kinase Inhibitor Inhibition 8.7 pIC50 - 3
pIC50 8.7 (IC50 2x10-9 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
MAP kinase interacting serine/threonine kinase 1 Inhibitor Inhibition 8.0 pIC50 - 3
pIC50 8.0 (IC50 1.1x10-8 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
LCK proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 7.8 pIC50 - 3
pIC50 7.8 (IC50 1.6x10-8 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
AMP kinase Inhibitor Inhibition 7.4 pIC50 - 3
pIC50 7.4 (IC50 4.1x10-8 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
ribosomal protein S6 kinase A1 Inhibitor Inhibition 6.7 pIC50 - 3
pIC50 6.7 (IC50 2.1x10-7 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 3 Inhibitor Inhibition >9.0 pIC50 - 3
pIC50 >9.0 (IC50 <1x10-9 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
kinase insert domain receptor Inhibitor Inhibition 8.4 pIC50 - 3
pIC50 8.4 (IC50 4x10-9 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
fms related tyrosine kinase 1 Inhibitor Inhibition 8.0 pIC50 - 3
pIC50 8.0 (IC50 1.1x10-8 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
EPH receptor A2 Inhibitor Inhibition 8.0 pIC50 - 3
pIC50 8.0 (IC50 1.1x10-8 M) [3]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
Ligand mentioned in the following text fields