prazosin

Ligand id: 503

Name: prazosin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 106.95
Molecular weight 383.16
XLogP 0.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1D-adrenoceptor Antagonist Inverse agonist 9.5 – 10.2 pKi - 5-6,9
pKi 9.5 – 10.2 [5-6,9]
α1B-adrenoceptor Antagonist Inverse agonist 9.6 – 9.9 pKi - 5-6,9
pKi 9.6 – 9.9 [5-6,9]
α1A-adrenoceptor Antagonist Inverse agonist 9.0 – 9.9 pKi - 2-3,5-6,9
pKi 9.0 – 9.9 [2-3,5-6,9]
α2C-adrenoceptor Antagonist Antagonist 6.7 – 8.0 pKi - 1,4,7
pKi 6.7 – 8.0 [1,4,7]
α2B-adrenoceptor Antagonist Antagonist 6.4 – 7.5 pKi - 1,4,7
pKi 6.4 – 7.5 [1,4,7]
α2A-adrenoceptor Antagonist Antagonist 5.3 – 6.5 pKi - 1,4,7
pKi 5.3 – 6.5 [1,4,7]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1A-adrenoceptor Antagonist Inverse agonist 9.5 pKi - 8
pKi 9.5 [8]
Ligand mentioned in the following text fields