tranylcypromine

Ligand id: 5281

Name: tranylcypromine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: tranylcypromine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 26.02
Molecular weight 133.09
XLogP 3.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Monoamine oxidase B Inhibitor Inhibition 4.7 pIC50 - 4
pIC50 4.7 (IC50 1.9x10-5 M) [4]
Monoamine oxidase A Inhibitor Inhibition 4.7 pIC50 - 4
pIC50 4.7 (IC50 2x10-5 M) [4]
lysine demethylase 1A Inhibitor Inhibition 4.4 pIC50 - 3
pIC50 4.4 (IC50 3.966x10-5 M) [3]
Description: In vitro KDM1A demethylation assay using purified human KDM1A protein and dimethylated H3K4 peptide as substrate.
Targets where the ligand is described in the comment field
Target Comment