Ligand id: 5281

Name: tranylcypromine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 26.02
Molecular weight 133.09
XLogP 3.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Gryglewski RJ, Bunting S, Moncada S, Flower RJ, Vane JR. (1976)
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.
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Site-directed mutagenesis of human prostacyclin synthase: Alteration of Cys441 of the Cys-pocket, and Glu347 and Arg350 of the EXXR motif.
FEBS Lett., 389 (3): 268-72. [PMID:8766713]
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A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.
MBio, 4 (1): e00558-12. [PMID:23386436]
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Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B.
Bioorg. Med. Chem., 12 (10): 2645-52. [PMID:15110846]