Ligand id: 5535

Name: chloroquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 28.16
Molecular weight 319.18
XLogP 4.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Chloroquine is active against only the erythrocytic forms of Plasmodium vivax, P. malariae, and susceptible strains of P. falciparum (but not the gametocytes of P. falciparum).
Selectivity at GPCRs
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
MRGPRX1 Hs Agonist Agonist 3.5 pEC50 - 1
pEC50 3.5 (EC50 2.97x10-4 M) [1]