Ligand id: 5535

Name: chloroquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 28.16
Molecular weight 319.18
XLogP 4.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
An antimalarial agent, but is also used off-label for other conditions/diseases.
Mechanism Of Action and Pharmacodynamic Effects
Chloroquine inhibits ferriprotoporphyrin IX (FP, a heme detoxifying enzyme) found in Plasmodium species. Chloroquine kills the malarial parasite by causing a build up of toxic heme by inhibiting the enzyme that normally converts it to non-toxic hamazion. Chloroquine may also form a complex with FP which is additionally highly toxic to the organism.
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