brivanib

Ligand id: 5671

Name: brivanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 84.67
Molecular weight 370.14
XLogP 2.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Secondary targets include VEGFR1 (fms-related tyrosine kinase 1) and FGFR1 (fibroblast growth factor receptor 1) [1].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fibroblast growth factor receptor 1 Inhibitor Inhibition 8.3 pKd - 2
pKd 8.3 (Kd 5x10-9 M) [2]
kinase insert domain receptor Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.5x10-8 M) [1]
fibroblast growth factor receptor 1 Inhibitor Inhibition 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.48x10-7 M) [1]
fms related tyrosine kinase 1 Inhibitor Inhibition 6.4 pIC50 - 1
pIC50 6.4 (IC50 3.8x10-7 M) [1]