brivanib

Ligand id: 5671

Name: brivanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 84.67
Molecular weight 370.14
XLogP 2.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Prodrug brivanib alinate
IUPAC Name
(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
International Nonproprietary Names
INN number INN
8879 brivanib alaninate
Synonyms
BMS 540215 | BMS-540215
Database Links
CAS Registry No. 649735-46-6
ChEMBL Ligand CHEMBL377300
PubChem CID 11234052
Search Google for chemical match using the InChIKey WCWUXEGQKLTGDX-LLVKDONJSA-N
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Search PubMed clinical trials brivanib alaninate
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Search UniChem for chemical match using the InChIKey WCWUXEGQKLTGDX-LLVKDONJSA-N
Search UniChem for chemicals with the same backbone WCWUXEGQKLTGDX
Wikipedia Brivanib
Comments
Brivanib (BMS-540215) is a potent ATP-competitive inhibitor of VEGFR2. Its discovery is reported in [1].
The International Non-proprietary Name (INN) brivanib alaninate has PubChem CID 11154925, and this represents the prodrug used in clinical trials.