midostaurin

Ligand id: 5702

Name: midostaurin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 77.73
Molecular weight 570.23
XLogP 6.71
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Midostaurin inhibits proliferation of cells carrying FLT3 translocations or single amino acid changes, and inhibits autophosphorylation of mutant FLT3 receptors [5].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 3 Inhibitor Inhibition 8.0 pKd - 2
pKd 8.0 (Kd 1.1x10-8 M) [2]
fms related tyrosine kinase 3 Inhibitor Inhibition 6.3 pIC50 - 5
pIC50 6.3 (IC50 5.28x10-7 M) [5]
Ligand mentioned in the following text fields