Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family

Formerly known as: PDGF (platelet-derived growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type III RTKs include PDGFR, CSF-1R (Ems), Kit and FLT3, which function as homo- or heterodimers. Endogenous ligands of PDGF receptors are homo- or heterodimeric: PDGFA, PDGFB, VEGFE and PDGFD (PDGFD, Q9GZP0) combine as homo- or heterodimers to activate homo- or heterodimeric PDGF receptors. SCF is a dimeric ligand for KIT. Ligands for CSF1R are either monomeric or dimeric glycoproteins, while the endogenous agonist for FLT3 is a homodimer.

Receptors

PDGFRα (platelet-derived growth factor receptor, alpha polypeptide) Show summary » More detailed page

PDGFRβ (platelet-derived growth factor receptor, beta polypeptide) Show summary » More detailed page

Kit (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) Show summary » More detailed page

CSFR (colony stimulating factor 1 receptor) Show summary » More detailed page

FLT3 (fms-related tyrosine kinase 3) Show summary » More detailed page

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How to cite this family page

Database page citation:

Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family. Accessed on 29/11/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=322.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol. 170: 1676–1705.