Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family

Formerly known as: PDGF (platelet-derived growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type III RTKs include PDGFR, CSF-1R (Ems), Kit and FLT3, which function as homo- or heterodimers. Endogenous ligands of PDGF receptors are homo- or heterodimeric: PDGFA, PDGFB, VEGFE and PDGFD (PDGFD, Q9GZP0) combine as homo- or heterodimers to activate homo- or heterodimeric PDGF receptors. SCF is a dimeric ligand for KIT. Ligands for CSF1R are either monomeric or dimeric glycoproteins, while the endogenous agonist for FLT3 is a homodimer.

Receptors

PDGFRα (platelet derived growth factor receptor alpha) Show summary » More detailed page

PDGFRβ (platelet derived growth factor receptor beta) Show summary » More detailed page

Kit (KIT proto-oncogene receptor tyrosine kinase) Show summary » More detailed page

CSFR (colony stimulating factor 1 receptor) Show summary » More detailed page

FLT3 (fms related tyrosine kinase 3) Show summary » More detailed page

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References

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How to cite this family page

Database page citation:

Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family. Accessed on 25/07/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=322.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.