AG 9

Ligand id: 5917

Name: AG 9

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 56.81
Molecular weight 184.06
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Gazit et al (1989) published results describing inhibition of EGF receptor kinase activity by this compound [3]. The IC50 for substrate phosphorylation was reported as >1250μM and the Ki >400μM. The source of the EGFR used in the in vitro experiments appears to be human A413 cells.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
epidermal growth factor receptor Hs Inhibitor Inhibition <3.4 pKi - 3
pKi <3.4 (Ki >4x10-4 M) [3]
Description: Measuring phosphorylation of the EGFR exogenous substrate polyGAT [poly(Glu6Ala3Tyr)]