AG 9

Ligand id: 5917

Name: AG 9

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 56.81
Molecular weight 184.06
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
p21 (RAC1) activated kinase 2 PAK2/PAK2 Hs Inhibitor Inhibition 58.1 106.0 99.0
microtubule affinity regulating kinase 3 nd/MARK3 Hs Inhibitor Inhibition 72.5
3-phosphoinositide dependent protein kinase 1 PDK1/PDK1(PDPK1) Hs Inhibitor Inhibition 72.6 113.0 111.0
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 74.5 112.0 103.0
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 77.0 95.0 86.0
protein tyrosine kinase 2 beta Pyk2/PYK2 Hs Inhibitor Inhibition 78.8 133.0 91.0
unc-51 like kinase 3 ULK3/ULK3 Hs Inhibitor Inhibition 79.6 103.0 95.0
MAP kinase interacting serine/threonine kinase 2 Mnk2/MNK2 Hs Inhibitor Inhibition 80.8 111.0 109.0
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 81.9 90.0 99.0
homeodomain interacting protein kinase 4 nd/HIPK1 Hs Inhibitor Inhibition 82.6
Displaying the top 10 targets  View all targets in screen »