Akt inhibitor X

Ligand id: 5922

Name: Akt inhibitor X

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 15.71
Molecular weight 344.17
XLogP 5.33
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Using recombinant human Akt1 (PKBα) and phosphorylation of downstream GSK-3β as a readout of Akt1 activity, Thimmaiah et al (2005) show that this compound almost completely blocks Akt activity at 5μM (see Figure 6 in the article) [4].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Pim-1 proto-oncogene, serine/threonine kinase Inhibitor Inhibition 5.9 pIC50 - 3
pIC50 5.9 (IC50 1.28x10-6 M) [3]