Cdk4 inhibitor II

Ligand id: 5951

Name: Cdk4 inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 62.58
Molecular weight 271.07
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 4 Hs Inhibitor Inhibition 6.7 pIC50 - 3
pIC50 6.7 (IC50 2x10-7 M) [3]
Description: CDK4/cyclin D1 complex used in assay
cyclin dependent kinase 2 Hs Inhibitor Inhibition <4.0 pIC50 - 3
pIC50 <4.0 (IC50 >1x10-4 M) [3]
Description: CDK2/cyclin A complex used in assay