bortezomib

Ligand id: 6391

Name: bortezomib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 11
Topological polar surface area 124.44
Molecular weight 384.2
XLogP 3.24
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Bortezomib has been shown to inhibit the chymotrypsin-like (aka β5) activity of the human 26S proteasome [4].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
proteasome subunit beta 5 Inhibitor Inhibition 7.7 pIC50 - 4
pIC50 7.7 (IC50 2x10-8 M) [4]
Ligand mentioned in the following text fields