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Synonyms: Amevive® | BG 9273 | BG 9712 | BG-9273 | BG-9712 | Lfa3Tip
alefacept is an approved drug (FDA (2003))
Compound class:
Peptide or derivative
Comment: This is a fusion protein of the CD2 ligand (CD58/LFA3, lymphocyte function associated antigen 3) linked to the Fc domain of IgG1. The construct is called LFA3TIP in [2].
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| Bioactivity Comments |
| The Miller et al. (1993) article does not provide a calculated IC50 value for LFA3TIP's inhibition of the CD2/LFA-3 interaction [2]. The inhibition is assessed by measuring rosetting of Jurkat/human red blood cells (with an approximate IC50 of 1-5μg/ml of protein from graphical data in Figure 3a), or by measuring inhibition of induced T cell proliferation (with LFA3TIP inhibition at approximately 86%) [2]. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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