acarbose

Ligand id: 6791

Name: acarbose

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 19
Hydrogen bond donors 14
Rotatable bonds 9
Topological polar surface area 321.17
Molecular weight 645.25
XLogP -5.53
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at mouse enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
maltase-glucoamylase Inhibitor Inhibition 7.6 – 8.1 pKi - 1
pKi 7.6 – 8.1 (Ki 2.8x10-8 – 9x10-9 M) [1]
Description: Affinity measured across splice variants of mouse MGAM catalytic subunit ctMGAM
Selectivity at pig enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
amylase, alpha 2A (pancreatic) Inhibitor Inhibition 4.4 pIC50 - 2
pIC50 4.4 (IC50 3.55x10-5 M) [2]