begacestat

Ligand id: 6979

Name: begacestat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 103.02
Molecular weight 390.95
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Inhibits amylois beta production with low nanomolar potency in cellular and cell-free assays of gamma-secretase function, and displaces a tritiated analog of GSI-953 from enriched gamma-secretase enzyme complexes with similar potency. Cellular assays of Notch cleavage show 16-fold selectivity over APP cleavage [1].
Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
presenilin 1 Inhibitor Inhibition 7.8 pEC50 - 1
pEC50 7.8 (EC50 1.48x10-8 M) [1]