ethopropazine

Ligand id: 7181

Name: ethopropazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 31.78
Molecular weight 312.17
XLogP 5.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have been unable to find publicly available bioactivity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
M1 receptor Rn Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 (Ki 3.1x10-9 M) [1]
Description: Displacement of [H]QNB binding in rat forebrain brain homogenate.
M2 receptor Rn Antagonist Antagonist 8.1 pKi - 1
pKi 8.1 (Ki 7.2x10-9 M) [1]
Description: Displacement of [H]QNB binding in rat hindbrain brain homogenate.