alimemazine

Ligand id: 7237

Name: alimemazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 298.15
XLogP 4.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed human molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. Quantitative data at bovine targets is published in [1] which reports anti-histaminergic and anti-muscarinic effects of alimemazine in bovine brain. Alimemazine antagonises [3H]QNB binding to bovine brain preparations (i.e. muscarinic acetylcholine receptor binding) with a Ki of 38nM [1].
Selectivity at bovine GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H1 receptor Antagonist Antagonist 9.1 pKi - 1
pKi 9.1 (Ki 7.2x10-10 M) [1]
Description: Inhibition of [3H]mepyramine binding to bovine brain membrane preparations in vitro.