etazolate

Ligand id: 7336

Name: etazolate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 81.4
Molecular weight 289.15
XLogP 2.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Multiple molecular modes of action have been reported for etazolate but these are not established as polypharmacology for any individual in vivo effect. Reports suggest that one of these, selective GABAA receptor modulation, stimulates alpha-secretase and consequent sAPPalpha production in rodents [1] .
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GABAA receptor β3 subunit Hs Allosteric modulator Binding 5.5 pIC50 - 3
pIC50 5.5 (IC50 3.5x10-6 M) [3]
Description: inhibition of [35S]TBPS binding