Ligand id: 7339

Name: CHF-5074

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 324.01
XLogP 4.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Note as a GSM the potency of gamma secretase inhibition is low
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
presenilin 1 Hs Inhibitor Binding 4.4 pEC50 - 2
pEC50 4.4 (EC50 4x10-5 M) [2]