Ligand id: 7371

Name: AQW051

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 25.36
Molecular weight 294.17
XLogP 4.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AQW051 demonstrates high affinity for nAChR α7 as a potent agonist [2]. Analogs have been published in a series of patents (but without SAR tables) including [1] where this is example B5.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
nicotinic acetylcholine receptor α7 subunit Hs Agonist Agonist 7.6 pKi - 2
pKi 7.6 (Ki 2.7x10-8 M) [125I]α- bungarotoxin binding assay [2]