Ligand id: 7371

Name: AQW051

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 25.36
Molecular weight 294.17
XLogP 4.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Di Paolo, Thérèse et. al. (2011)
Use of nicotinic acetylcholine receptor alpha 7 activators.
Patent number: WO2011036167. Assignee: Novartis. Priority date: 22/09/2009. Publication date: 31/03/2011.
2. Hurth K, et. al. 
MEDI 222: Identification of AQW051, an alpha7 nicotinic acetylcholine receptor partial agonist for the treatment of cognitive impairment associated with schizophrenia.
Accessed on 06/04/2014. Modified on 06/04/2014. ACS Med Chem Meeting Abstracts, March 2014,